NeuroHormone-Complete-Plus-Profile-saliva-urine NeuroHormone-Complete-Plus-Profile-saliva-urine
NeuroHormone Complete Plus Profile; saliva & urine NeuroHormone Complete Plus Profile; saliva & urine NeuroHormone Complete Plus Profile; saliva & urine

NeuroHormone Complete Plus Profile; saliva & urine

The NeuroHormone Complete Plus Profile combines the Comprehensive Plus Hormone Profile and the Neurobasic Profile. The Comprehensive Plus Profile expands on the Comprehensive Profile and includes estrone (E1), estriol (E3), and the Estrogen Quotient (EQ). Henry Lemon MD developed the Estrogen Quotient, a simple ratio of the cancer protective E3 relative to the proliferative estrogens E1 and E2, to assess breast cancer risk. A lower number (<1.0) indicates increased risk, and a higher number (>1.0) signifies lower risk. Dr. Lemon stated that for maximum protection, an optimal EQ is >1.5. This information may be extrapolated to provide information on other estrogen driven disorders. Because the research on the EQ focused on women, no reference range has been established for males, however some health care providers appreciate the information the additional estrogens provide in relation to prostate health. 

Urinary neurotransmitter levels provide an overall assessment of the body's ability to make and break down neurotransmitters and are representative of whole body levels. Neurotransmitters are secreted all through the body, in neurons of both the central and peripheral nervous systems, as well as the gastrointestinal microbiome. The enzymes, cofactors and precursors in neurotransmitter metabolism in general are the same in the periphery and in the central nervous system. Therefore abnormal levels of neurotransmitters in urine may provide important clinical information, and may be associated with many symptoms including cognitive and mood concerns, diminished drive, fatigue and sleep difficulties, cravings, addictions and pain, and abnormal abundance and diversity within the gastrointestinal microbiome.

Please note: If you suspect that your patient has kidney damage or compromised renal function, a 24-hour collection is a better option to accurately assess excretion of the neurotransmitters. A 24-hour neurotransmitter test can be ordered separately from this profile.

Click here to learn more about 24-hour vs. spot collections for neurotransmitters.


Useful for:

  • Increased risk of developing breast cancer 
  • History of breast cancer or other hormonally sensitive cancers 
  • Personal or family history of autoimmune disease 
  • PCOS 
  • Mood concerns, such as depression, anxiety
  • Diminished energy/fatigue
  • Insomnia
  • Cognitive concerns such as forgetfulness, inattention, brain fog
  • Addiction, dependency
  • Obsessions and cravings
  • Chronic illness, immune deficiency
  • Pain
  • Low libido, sexual dysfunction

Turnaround Time

5 to 7 days

Note: Turnaround times on results are an estimate and are not guaranteed. The lab may need additional time due to holidays, confirmation/repeat testing, etc. You can contact us to discuss when your results should be ready.

Analytes Tested

Click any analyte name for additional clinical information, including reference ranges, specimen collection, stability and rejection criteria.

List price applies when filing with insurance or Medicare, or when billing a patient directly. Prompt payment pricing applies when billing to a physician account or prepayment is received with the test.

Doctor's Data offers profiles containing multiple analytes. *Multiple analytes may be billed under a single CPT code. Many analytes can be ordered individually. Pricing may vary. Click on a specific analyte for more information or read our detailed billing and payment policies.

The CPT codes listed on our website are for informational purposes only. This information is our interpretation of CPT coding requirements and may not necessarily be correct. You are advised to consult the CPT Coding Manual published by the American Medical Association. Doctor's Data, Inc. takes no responsibility for billing errors due to your use of any CPT information from our website.

Sign in at the top of any page to view pricing and order tests. Or click here to create an account. You may also contact us for assistance placing an order.

Detailed Information

The Comprehensive Plus Hormone Profile reports hormone levels and also calculates two important ratios. The Estrogen Quotient is a simple ratio of the cancer protective E3 relative to the proliferative estrogens E1 and E2, to assess breast cancer risk. The Pg/E2 ratio assesses the relationship between estradiol, which can drive cellular proliferation, and progesterone, which mitigates that growth and potentiates cellular differentiation.

Hormones are powerful molecules essential for maintaining physical and mental health. We frequently think of estrogen as being a female hormone, and testosterone as being a male hormone. But men AND women make both, plus several more that need to be in balance for optimum health. An imbalance of any one hormone can throw your physical and mental health out of balance, causing aggravating and even serious health problems.

One size does not fit all when it comes to hormones. For decades western medicine has prescribed hormone replacement therapy as if everyone needed the same thing and the same amount. Nothing could be further from the truth. Your hormones are like your fingerprints and in order to achieve optimal health, you need to know what your specific imbalances are. Female and male hormone tests can help identify these imbalances.

There are several ways to test for hormones (saliva, serum and urine). Saliva is the best method to test the active/bioavailable portion of hormones, which are reflective of tissue levels. If your patient is seeking bio-identical hormone replacement (BHRT), you'll need to know active hormone levels. In addition, if using a topical (transdermal) hormone preparation for treatment, saliva testing is the most accurate tool to measure and monitor hormone status.

Analysis of urinary neurotransmitters is non-invasive; testing may provide therapeutic opportunities that improve clinical success and patient health outcomes.

Neurotransmitters are secreted from pre-synaptic neurons into the synapse between nerve cells to stimulate receptors on post-synaptic neurons. The neurotransmitters are all produced from essential aromatic amino acids. Neurotransmitter metabolism may be mediated by a variety of enzymes expressed differently throughout the body. Circulating levels of neurotransmitters and metabolites may have distinctive sources.

A lack of nutritional cofactors (vitamins, minerals) required for normal enzyme function may decrease enzyme function and neurotransmitter levels. Neurotransmitter receptors and metabolic enzymes may be subject to mutations and single nucleotide polymorphisms (SNPs) that may affect receptor or enzyme function. Normal neurotransmitter receptor function is also necessary for normal neurotransmitter activity. Neurotransmitter levels may be influenced by many factors, such as diet, lifestyle, age, sex, body mass index, hormone imbalance, environmental exposures, infection, chronic inflammation, and nicotine use.

Neurotransmitter analysis provides an overall assessment of a patient's ability to synthesize and metabolize neurotransmitters, which must occur in both the peripheral nervous system and behind the blood brain barrier (BBB). Alterations in urinary neurotransmitter status may result from a variety of conditions including metabolic disorders, mood/behavioral disorders, environmental exposures or (rarely) the presence of certain tumors. Evaluation of neurotransmitters may provide increased clarity about a patient's health and functional status.

Information gained through neurotransmitter testing may provide therapeutic opportunities that improve clinical success and patient health outcomes. Associations between urinary neurotransmitter levels and health conditions have been documented in scientific literature and may provide valuable insight as part of a comprehensive health assessment.